Using Genetically Engineered Mice for Radiation Research
نویسندگان
چکیده
منابع مشابه
Assessing the Radiation Response of Lung Cancer with Different Gene Mutations Using Genetically Engineered Mice
PURPOSE Non-small cell lung cancers (NSCLC) are a heterogeneous group of carcinomas harboring a variety of different gene mutations. We have utilized two distinct genetically engineered mouse models of human NSCLC (adenocarcinoma) to investigate how genetic factors within tumor parenchymal cells influence the in vivo tumor growth delay after one or two fractions of radiation therapy (RT). MAT...
متن کاملPredicting drug responsiveness in human cancers using genetically engineered mice.
PURPOSE To use genetically engineered mouse models (GEMM) and orthotopic syngeneic murine transplants (OST) to develop gene expression-based predictors of response to anticancer drugs in human tumors. These mouse models offer advantages including precise genetics and an intact microenvironment/immune system. EXPERIMENTAL DESIGN We examined the efficacy of 4 chemotherapeutic or targeted antica...
متن کاملGenetically Engineered Mice Predicting Drug Responsiveness in Human Cancers Using
Purpose: To use genetically engineered mouse models (GEMM) and orthotopic syngeneic murine transplants (OST) to develop gene expression-based predictors of response to anticancer drugs in human tumors. These mouse models offer advantages including precise genetics and an intact microenvironment/
متن کاملCongenital hydrocephalus in genetically engineered mice.
There is evidence that genetic factors play a role in the complex multifactorial pathogenesis of hydrocephalus. Identification of the genes involved in the development of this neurologic disorder in animal models may elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans. The authors report here a brief summary of findings from 12 lines of ge...
متن کاملBerul engineered mice Electrophysiological phenotyping in genetically
24 times a year (twice monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD systems with techniques linking genes and pathways to physiology, from prokaryotes to eukaryotes. It is published publishes results of a wide variety of studies from human and from informative model Physiological Genomics
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiation Research
سال: 2011
ISSN: 0033-7587,1938-5404
DOI: 10.1667/rrxx35.1